Assuming a post-scarcity world, the big challenge will be how to satisfy the human need for justice. At the very least, there will be two systems of justice: one for the wealthy celebrities and another for the rest. The masses will have very little opportunity to seek justice from the wealthy, especially once democracy is replaced or rendered lame from politics of division of ever smaller identity groups. Over time (especially over generations), we will learn to satisfy our needs for justice though non-governmental means.
Unlike skepticism of knowledge or of ability to know the truth, the modern skepticism is a skepticism of having enough data.
In present government, we often set absolutes in policy positions. These absolutes are claims of truth or natural law. When we set an absolute policy position, we categorically reject any policy that contradicts it. I think this is a bad way to govern because by rejecting as absolutely wrong certain things that people will do anyway we lose any ability to manage that activity. Our only response to a violation of an absolute policy position is to demand that everyone stop doing it. It would be more productive if we tolerate everything so that we can offer prescriptions for more acceptable or less offense methods of doing the same thing.